Michael Honer Selected Research

2- chloro- 4- (1- (4- fluorophenyl)- 2,5- dimethyl- 1H- imidazol- 4- ylethynyl)pyridine

4/2015	Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
2/2015	Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

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Michael Honer Research Topics

Disease

17	Neoplasms (Cancer) 10/2020 - 05/2003
5	Carcinoma (Carcinomatosis) 01/2007 - 07/2005
4	Alzheimer Disease (Alzheimer's Disease) 12/2018 - 05/2012
4	Hypoxia (Hypoxemia) 10/2011 - 03/2006
3	Fragile X Syndrome (Martin Bell Syndrome) 04/2015 - 11/2011
3	Renal Cell Carcinoma (Grawitz Tumor) 01/2006 - 05/2003
2	Cognitive Dysfunction 01/2021 - 02/2013
2	Schizophrenia (Dementia Praecox) 01/2021 - 05/2012
2	Pain (Aches) 10/2020 - 04/2015
2	Parkinson Disease (Parkinson's Disease) 02/2015 - 11/2011
2	Narcolepsy 05/2012 - 03/2011
2	Body Weight (Weight, Body) 10/2011 - 08/2009
2	Neoplasm Metastasis (Metastasis) 11/2010 - 01/2007
2	Ovarian Neoplasms (Ovarian Cancer) 01/2007 - 01/2006
2	Neuroblastoma 01/2006 - 07/2005
2	Soft Tissue Infections 10/2004 - 03/2004
1	Neuroinflammatory Diseases 12/2021
1	Down Syndrome (Down's Syndrome) 01/2021
1	Intellectual Disability (Idiocy) 01/2021
1	Autoimmune Diseases (Autoimmune Disease) 10/2020
1	Epilepsy (Aura) 01/2018
1	Autism Spectrum Disorder 01/2018
1	Tuberous Sclerosis (Bourneville's Disease) 01/2018
1	Seizures (Absence Seizure) 01/2018
1	Disorders of Excessive Somnolence (Hypersomnia) 04/2015
1	Lethargy 04/2015
1	Mental Disorders (Mental Disorder) 02/2015
1	Dyskinesias (Dyskinesia) 02/2015
1	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 02/2015
1	Osteosarcoma (Osteogenic Sarcoma) 08/2013
1	Nervous System Diseases (Neurological Disorders) 05/2012
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 10/2011
1	Cysts 10/2011
1	Proteinuria 10/2011
1	Cataplexy 03/2011
1	Sleepiness 03/2011
1	Prostatic Neoplasms (Prostate Cancer) 02/2011
1	Inflammation (Inflammations) 11/2010
1	Brain Diseases (Brain Disorder) 05/2010

Drug/Important Bio-Agent (IBA)

5	fluoromisonidazoleIBA 08/2013 - 03/2006
4	Proteins (Proteins, Gene)FDA Link 12/2021 - 07/2005
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 08/2010
4	BombesinIBA 01/2012 - 09/2008
4	Bombesin Receptors (Bombesin Receptor)IBA 01/2012 - 09/2008
3	LigandsIBA 12/2021 - 05/2003
3	Pharmaceutical PreparationsIBA 01/2021 - 11/2011
3	Metabotropic Glutamate 5 ReceptorIBA 01/2018 - 11/2011
3	Glucose (Dextrose)FDA LinkGeneric 08/2013 - 06/2006
3	Folic Acid (Vitamin M)FDA LinkGeneric 11/2010 - 07/2006
3	AntibodiesIBA 11/2010 - 01/2006
3	AcidsIBA 11/2010 - 07/2006
3	Monoclonal AntibodiesIBA 01/2007 - 07/2005
2	Amyloid (Amyloid Fibrils)IBA 12/2018 - 01/2018
2	2- chloro- 4- (1- (4- fluorophenyl)- 2,5- dimethyl- 1H- imidazol- 4- ylethynyl)pyridineIBA 04/2015 - 02/2015
2	pyridineIBA 04/2015 - 02/2015
2	Indicators and Reagents (Reagents)IBA 08/2013 - 11/2010
2	Therapeutic UsesIBA 02/2013 - 01/2007
2	Peptides (Polypeptides)IBA 01/2012 - 02/2011
2	2-(4-chlorophenylthio)triethylamineIBA 01/2007 - 05/2003
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 07/2006 - 10/2004
2	CopperIBA 02/2005 - 05/2003
1	basmisanilIBA 01/2021
1	CannabinoidsIBA 10/2020
1	trans-sodium crocetinate (crocetin)IBA 01/2018
1	Amyloid beta-PeptidesIBA 01/2017
1	Antidepressive Agents (Antidepressants)IBA 04/2015
1	antineoplaston A10 (A 10)IBA 02/2015
1	Levodopa (L Dopa)FDA LinkGeneric 02/2015
1	Diazepam (Valium)FDA LinkGeneric 02/2015
1	FluoridesIBA 08/2013
1	gamma-Aminobutyric Acid (GABA)IBA 02/2013
1	3- bromo- 10- difluoromethyl- 9H- imidazo(1,5- a)(1,2,4)triazolo(1,5- d)(1,4)benzodiazepineIBA 02/2013
1	Histamine (Histamine Dihydrochloride)FDA Link 05/2012
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2011
1	Glutamic Acid (Glutamate)FDA Link 11/2011
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2011
1	Cre recombinaseIBA 03/2011
1	OrexinsIBA 03/2011
1	Orexin ReceptorsIBA 03/2011
1	fluoroethylcholineIBA 02/2011
1	Hyaluronic Acid (Hyaluronan)IBA 11/2010
1	compound 18IBA 10/2010
1	TOR Serine-Threonine KinasesIBA 08/2010
1	Angiogenesis InhibitorsIBA 08/2010
1	Everolimus FDA Link 08/2010
1	epothilone B (EPO906)IBA 08/2010
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 05/2010
1	LuciferasesIBA 08/2009
1	3- (6- methylpyridin- 2- ylethynyl)cyclohex- 2- enone- O- methyloximeIBA 08/2009
1	SiliconIBA 09/2008
1	Amino Acids FDA Link 01/2007
1	Copper-67IBA 01/2007
1	Benzoic Acid (Potassium Benzoate)FDA Link 01/2007
1	acivicin (AT 125)IBA 07/2006
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 06/2006

Therapy/Procedure

7	Therapeutics 01/2017 - 10/2004
2	Drug Therapy (Chemotherapy) 10/2011 - 08/2010
2	Radioimmunotherapy 01/2007 - 07/2005
1	Radiotherapy 01/2012
1	Injections 01/2007